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Pemetrexed Disodium API Global Market

Pemetrexed Disodium API Global Market

Global Pemetrexed Disodium API Market Research Report 2025

This report on the global pemetrexed disodium api market research report 2025 offers a comprehensive analysis of market size, growth drivers, emerging trends, region

Pages: 210

Format: PDF

Date: 12-2025

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Global Pemetrexed Disodium API Market –Overview

The Global Pemetrexed Disodium API Market is a specialized segment of the oncology active pharmaceutical ingredients industry, supporting the production of antifolate chemotherapeutic drugs primarily used in the treatment of non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma. In 2024, the market was valued at USD xxxx and is projected to reach USD xxxx by 2035, growing at a CAGR of xx% during the forecast period 2025–2035.

Market growth is driven by the sustained global cancer burden, continued inclusion of pemetrexed-based regimens in standard oncology protocols, and the expansion of generic injectable oncology drugs following patent expirations. As a complex and high-value API, pemetrexed disodium requires advanced synthetic chemistry, stringent impurity control, and full compliance with global GMP and regulatory standards. Increasing oncology healthcare spending and growing access to cancer treatment in emerging economies further support long-term demand.

Impact of COVID-19 on the Pemetrexed Disodium API Market

The COVID-19 pandemic caused short-term disruptions in the pemetrexed disodium API market during 2020 due to interruptions in global supply chains, manufacturing slowdowns, and delays in oncology treatment schedules. Regulatory inspections and logistics were temporarily affected, particularly for cross-border API shipments.

However, demand for essential oncology medications remained structurally resilient. As healthcare systems normalized, API production and procurement recovered steadily. Post-pandemic, pharmaceutical manufacturers have emphasized supply-chain resilience, dual sourcing, and regional manufacturing, strengthening long-term market stability.

Global Pemetrexed Disodium API Market Segmentation

By Purity

Purity ≥ 98%

  • Standard grade used in regulated and semi-regulated markets
  • Suitable for cost-sensitive generic injectable manufacturing
  • Stable demand across emerging and developing regions

Purity ≥ 99%

  • High-purity grade preferred in highly regulated markets
  • Ensures enhanced safety, stability, and impurity compliance
  • Increasing adoption by multinational injectable manufacturers
  • Higher margin segment due to complex synthesis and purification

By Application

Pemetrexed Disodium Injection

  • Dominant application segment
  • Used in hospital-based and specialty oncology settings
  • Growth driven by increasing chemotherapy volumes and generic penetration
  • Strong demand from public healthcare systems and oncology centers

Others

  • Includes R&D, formulation development, and limited specialty uses
  • Smaller volume but strategically important for lifecycle management

Competitive Landscape – Key Players Analysis

The pemetrexed disodium API market is moderately concentrated, with a limited number of qualified manufacturers possessing the technical capability and regulatory approvals required for oncology APIs.

  • Dr. Reddy's Laboratories
    Major global supplier with strong oncology API and injectable portfolio and broad regulatory approvals.
  • Qilu Pharmaceutical
    Integrated API and formulation manufacturer with strong presence in oncology generics.
  • Farmhispania Group
    European API specialist supplying complex and regulated oncology APIs.
  • Gland Chemicals
    Focuses on high-potency and injectable oncology APIs with export orientation.
  • ChemWerth
    Provides regulatory-compliant API sourcing for global pharmaceutical companies.
  • Suzhou Lixin Pharmaceutical
    Supplies oncology APIs to domestic and export markets.
  • Rochem International
    Active in oncology and specialty APIs for regulated and semi-regulated markets.
  • Chongqing Pharmaceutical Research
    Engaged in development and manufacturing of complex APIs, including oncology drugs.

Regional Analysis

North America

  • High-value, regulation-driven market
  • Demand supported by generic injectable oncology drugs
  • United States dominates regional consumption

Europe

  • Strong adoption of pemetrexed generics in public healthcare systems
  • Stringent quality and pharmacovigilance standards
  • Germany, France, and the U.K. are major markets

Asia-Pacific

  • Fastest-growing regional market
  • Driven by rising cancer incidence, expanding healthcare access, and large-scale API manufacturing
  • China and India dominate production and regional supply

South America

  • Moderate growth supported by increasing oncology treatment coverage
  • Brazil and Argentina are key demand centers

Middle East & Africa

  • Emerging market with improving oncology infrastructure
  • Growth driven by public healthcare investment and imported generics
  • Saudi Arabia and South Africa act as regional hubs

DRTO Analysis (Drivers, Restraints, Trends & Opportunities)

Drivers

  • Rising global incidence of non-small cell lung cancer (NSCLC) and mesothelioma
  • Continued inclusion of pemetrexed-based regimens in standard oncology treatment protocols
  • Expansion of generic injectable oncology drugs following patent expirations
  • Growing access to cancer care in emerging economies
  • Increasing government and private investment in oncology healthcare infrastructure

Restraints

  • Complex multistep synthesis and stringent impurity control requirements
  • High compliance costs related to GMP, pharmacopoeial, and regulatory standards
  • Volatility in raw material and intermediate sourcing
  • Pricing pressure due to increasing competition among generic suppliers

Trends

  • Shift toward higher-purity (≥99%) pemetrexed disodium APIs for regulated markets
  • Strengthening of supply-chain resilience and dual sourcing strategies
  • Capacity expansion and backward integration by Indian and Chinese manufacturers
  • Greater focus on process optimization and yield improvement
  • Increasing preference for long-term supply agreements with injectable manufacturers

Opportunities

  • Growth of oncology generics in Asia-Pacific, Latin America, and Middle East & Africa
  • Expansion of injectable manufacturing capacity globally
  • Increasing public healthcare procurement of essential cancer medicines
  • Export opportunities to semi-regulated and emerging markets
  • Technological innovation in cost-efficient and scalable synthesis routes

SWOT Analysis – Key Market Players

Strengths

Weaknesses

Expertise in complex oncology API synthesis

High capital and compliance intensity

Established regulatory approvals in major markets

Dependence on oncology treatment volumes

Strong relationships with injectable formulators

Limited flexibility for rapid capacity scale-up

Opportunities

Threats

Rising demand for high-purity oncology APIs

Aggressive price competition from low-cost producers

Expansion into regulated and semi-regulated markets

Regulatory inspection and compliance risks

Vertical integration into formulations

Emergence of alternative cancer therapies
     

Porter’s Five Forces Analysis

1. Threat of New Entrants – Low

  • High technical complexity and long regulatory approval timelines
  • Significant investment required for GMP facilities and analytical validation

2. Bargaining Power of Suppliers – Moderate

  • Dependence on specialized chemical intermediates
  • Supplier quality directly impacts API compliance and yield

3. Bargaining Power of Buyers – High

  • Large injectable manufacturers and hospital suppliers exert strong pricing pressure
  • Buyers demand consistent quality, audits, and secure long-term supply

4. Threat of Substitutes – Low to Moderate

  • Alternative oncology drugs exist, but pemetrexed remains a standard-of-care component
  • No direct substitute with identical antifolate mechanism in many regimens

5. Competitive Rivalry – Moderate

  • Limited number of globally qualified suppliers
  • Competition based on purity, regulatory approvals, reliability, and cost

Competitive Landscape – Strategic Positioning

Company

Market Presence

Core Strength

Value Segment

Dr. Reddy's Laboratories

Global

Regulatory strength & scale

Premium

Qilu Pharmaceutical

Asia / Global

Integrated API & formulations

Mid

Farmhispania Group

Europe / Global

Complex oncology APIs

Mid–High

Gland Chemicals

Global

Injectable-focused APIs

Mid–High

Suzhou Lixin Pharmaceutical

Regional / Export

Cost-efficient production

Mid

ChemWerth

Global

Regulatory-compliant sourcing

Mid

Investor-Focused Executive Summary

The Global Pemetrexed Disodium API Market is a defensive and regulation-driven oncology API segment, characterized by high entry barriers, stable demand, and long product life cycles. While volume growth is moderate, value growth is supported by the increasing preference for high-purity (≥99%) APIs, stricter regulatory scrutiny, and sustained inclusion of pemetrexed in first-line and maintenance chemotherapy regimens.

Asia-Pacific, led by India and China, continues to strengthen its position as the primary manufacturing hub due to cost advantages and improving regulatory capabilities. North America and Europe remain premium demand regions, prioritizing quality, compliance, and supply reliability.

From an investment perspective, companies best positioned for long-term value creation demonstrate:

  • Proven GMP compliance and global regulatory approvals
  • Capability to consistently manufacture ≥99% purity pemetrexed disodium API
  • Strong relationships with injectable oncology drug manufacturers
  • Robust supply-chain management and process optimization expertise

Overall, the market offers predictable long-term returns, with selective upside from premium purity segments, supply consolidation, and expanding global access to oncology treatment.

 

1. Market Overview of Pemetrexed Disodium API Market
    1.1 Pemetrexed Disodium API Market Market Overview
        1.1.1 Pemetrexed Disodium API Market Product Scope
        1.1.2 Market Status and Outlook
    1.2 Pemetrexed Disodium API Market Market Size by Regions:
    1.3 Pemetrexed Disodium API Market Historic Market Size by Regions
    1.4 Pemetrexed Disodium API Market Forecasted Market Size by Regions
    1.5 Covid-19 Impact on Key Regions, Keyword Market Size YoY Growth
        1.5.1 North America
        1.5.2 East Asia
        1.5.3 Europe
        1.5.4 South Asia
        1.5.5 Southeast Asia
        1.5.6 Middle East
        1.5.7 Africa
        1.5.8 Oceania
        1.5.9 South America
        1.5.10 Rest of the World
    1.6 Coronavirus Disease 2019 (Covid-19) Impact Will Have a Severe Impact on Global Growth
        1.6.1 Covid-19 Impact: Global GDP Growth,  Projections
        1.6.2 Covid-19 Impact: Commodity Prices Indices
        1.6.3 Covid-19 Impact: Global Major Government Policy
2. Covid-19 Impact Pemetrexed Disodium API Market Sales Market by Type
    2.1 Global Pemetrexed Disodium API Market Historic Market Size by Type
    2.2 Global Pemetrexed Disodium API Market Forecasted Market Size by Type
    2.3 Purity ? 98 %
    2.4 Purity ? 99 %
3. Covid-19 Impact Pemetrexed Disodium API Market Sales Market by Application
    3.1 Global Pemetrexed Disodium API Market Historic Market Size by Application
    3.2 Global Pemetrexed Disodium API Market Forecasted Market Size by Application
    3.3 Pemetrexed Disodium Injection
    3.4 Others
4. Covid-19 Impact Market Competition by Manufacturers
    4.1 Global Pemetrexed Disodium API Market Production Capacity Market Share by Manufacturers
    4.2 Global Pemetrexed Disodium API Market Revenue Market Share by Manufacturers
    4.3 Global Pemetrexed Disodium API Market Average Price by Manufacturers
5. Company Profiles and Key Figures in Pemetrexed Disodium API Market Business
    5.1 Farmhispania Group
        5.1.1 Farmhispania Group Company Profile
        5.1.2 Farmhispania Group Pemetrexed Disodium API Market Product Specification
        5.1.3 Farmhispania Group Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.2 Tecoland
        5.2.1 Tecoland Company Profile
        5.2.2 Tecoland Pemetrexed Disodium API Market Product Specification
        5.2.3 Tecoland Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.3 Chem Genix
        5.3.1 Chem Genix Company Profile
        5.3.2 Chem Genix Pemetrexed Disodium API Market Product Specification
        5.3.3 Chem Genix Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.4 Dr. Reddy's Laboratories
        5.4.1 Dr. Reddy's Laboratories Company Profile
        5.4.2 Dr. Reddy's Laboratories Pemetrexed Disodium API Market Product Specification
        5.4.3 Dr. Reddy's Laboratories Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.5 ChemWerth
        5.5.1 ChemWerth Company Profile
        5.5.2 ChemWerth Pemetrexed Disodium API Market Product Specification
        5.5.3 ChemWerth Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.6 Gland Chemicals
        5.6.1 Gland Chemicals Company Profile
        5.6.2 Gland Chemicals Pemetrexed Disodium API Market Product Specification
        5.6.3 Gland Chemicals Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.7 Suzhou Lixin Pharmaceutical
        5.7.1 Suzhou Lixin Pharmaceutical Company Profile
        5.7.2 Suzhou Lixin Pharmaceutical Pemetrexed Disodium API Market Product Specification
        5.7.3 Suzhou Lixin Pharmaceutical Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.8 Rochem International
        5.8.1 Rochem International Company Profile
        5.8.2 Rochem International Pemetrexed Disodium API Market Product Specification
        5.8.3 Rochem International Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.9 Qilu Pharmaceutial
        5.9.1 Qilu Pharmaceutial Company Profile
        5.9.2 Qilu Pharmaceutial Pemetrexed Disodium API Market Product Specification
        5.9.3 Qilu Pharmaceutial Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
    5.10 Chongqing Pharmaceutical Research
        5.10.1 Chongqing Pharmaceutical Research Company Profile
        5.10.2 Chongqing Pharmaceutical Research Pemetrexed Disodium API Market Product Specification
        5.10.3 Chongqing Pharmaceutical Research Pemetrexed Disodium API Market Production Capacity, Revenue, Price and Gross Margin
6. North America
    6.1 North America Pemetrexed Disodium API Market Market Size
    6.2 North America Pemetrexed Disodium API Market Key Players in North America
    6.3 North America Pemetrexed Disodium API Market Market Size by Type
    6.4 North America Pemetrexed Disodium API Market Market Size by Application
7. East Asia
    7.1 East Asia Pemetrexed Disodium API Market Market Size
    7.2 East Asia Pemetrexed Disodium API Market Key Players in North America
    7.3 East Asia Pemetrexed Disodium API Market Market Size by Type
    7.4 East Asia Pemetrexed Disodium API Market Market Size by Application
8. Europe
    8.1 Europe Pemetrexed Disodium API Market Market Size
    8.2 Europe Pemetrexed Disodium API Market Key Players in North America
    8.3 Europe Pemetrexed Disodium API Market Market Size by Type
    8.4 Europe Pemetrexed Disodium API Market Market Size by Application
9. South Asia
    9.1 South Asia Pemetrexed Disodium API Market Market Size
    9.2 South Asia Pemetrexed Disodium API Market Key Players in North America
    9.3 South Asia Pemetrexed Disodium API Market Market Size by Type
    9.4 South Asia Pemetrexed Disodium API Market Market Size by Application
10. Southeast Asia
    10.1 Southeast Asia Pemetrexed Disodium API Market Market Size
    10.2 Southeast Asia Pemetrexed Disodium API Market Key Players in North America
    10.3 Southeast Asia Pemetrexed Disodium API Market Market Size by Type
    10.4 Southeast Asia Pemetrexed Disodium API Market Market Size by Application
11. Middle East
    11.1 Middle East Pemetrexed Disodium API Market Market Size
    11.2 Middle East Pemetrexed Disodium API Market Key Players in North America
    11.3 Middle East Pemetrexed Disodium API Market Market Size by Type
    11.4 Middle East Pemetrexed Disodium API Market Market Size by Application
12. Africa
    12.1 Africa Pemetrexed Disodium API Market Market Size
    12.2 Africa Pemetrexed Disodium API Market Key Players in North America
    12.3 Africa Pemetrexed Disodium API Market Market Size by Type
    12.4 Africa Pemetrexed Disodium API Market Market Size by Application
13. Oceania
    13.1 Oceania Pemetrexed Disodium API Market Market Size
    13.2 Oceania Pemetrexed Disodium API Market Key Players in North America
    13.3 Oceania Pemetrexed Disodium API Market Market Size by Type
    13.4 Oceania Pemetrexed Disodium API Market Market Size by Application
14. South America
    14.1 South America Pemetrexed Disodium API Market Market Size
    14.2 South America Pemetrexed Disodium API Market Key Players in North America
    14.3 South America Pemetrexed Disodium API Market Market Size by Type
    14.4 South America Pemetrexed Disodium API Market Market Size by Application
15. Rest of the World
    15.1 Rest of the World Pemetrexed Disodium API Market Market Size
    15.2 Rest of the World Pemetrexed Disodium API Market Key Players in North America
    15.3 Rest of the World Pemetrexed Disodium API Market Market Size by Type
    15.4 Rest of the World Pemetrexed Disodium API Market Market Size by Application
16 Pemetrexed Disodium API Market Market Dynamics
    16.1 Covid-19 Impact Market Top Trends
    16.2 Covid-19 Impact Market Drivers
    16.3 Covid-19 Impact Market Challenges
    16.4 Porter?s Five Forces Analysis
18 Regulatory Information
17 Analyst's Viewpoints/Conclusions
18 Appendix
    18.1 Research Methodology
        18.1.1 Methodology/Research Approach
        18.1.2 Data Source
    18.2 Disclaimer

Global Pemetrexed Disodium API Market Segmentation

By Purity

Purity ≥ 98%

  • Standard grade used in regulated and semi-regulated markets
  • Suitable for cost-sensitive generic injectable manufacturing
  • Stable demand across emerging and developing regions

Purity ≥ 99%

  • High-purity grade preferred in highly regulated markets
  • Ensures enhanced safety, stability, and impurity compliance
  • Increasing adoption by multinational injectable manufacturers
  • Higher margin segment due to complex synthesis and purification

By Application

Pemetrexed Disodium Injection

  • Dominant application segment
  • Used in hospital-based and specialty oncology settings
  • Growth driven by increasing chemotherapy volumes and generic penetration
  • Strong demand from public healthcare systems and oncology centers

Others

  • Includes R&D, formulation development, and limited specialty uses
  • Smaller volume but strategically important for lifecycle management

Competitive Landscape – Key Players Analysis

The pemetrexed disodium API market is moderately concentrated, with a limited number of qualified manufacturers possessing the technical capability and regulatory approvals required for oncology APIs.

  • Dr. Reddy's Laboratories
    Major global supplier with strong oncology API and injectable portfolio and broad regulatory approvals.
  • Qilu Pharmaceutical
    Integrated API and formulation manufacturer with strong presence in oncology generics.
  • Farmhispania Group
    European API specialist supplying complex and regulated oncology APIs.
  • Gland Chemicals
    Focuses on high-potency and injectable oncology APIs with export orientation.
  • ChemWerth
    Provides regulatory-compliant API sourcing for global pharmaceutical companies.
  • Suzhou Lixin Pharmaceutical
    Supplies oncology APIs to domestic and export markets.
  • Rochem International
    Active in oncology and specialty APIs for regulated and semi-regulated markets.
  • Chongqing Pharmaceutical Research
    Engaged in development and manufacturing of complex APIs, including oncology drugs.

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